Emerging evidence suggests the healthy human lung may modulate circulating neutrophil function, for example by de-priming neutrophils. Primed neutrophils are retained in the human lung. Priming is a key step in achieving maximal neutrophil activation and a prerequisite for neutrophil-mediated tissue injury. Prior exposure to inflammatory mediators “primes” neutrophils, significantly lowering the threshold for activation by subsequent stimuli. None of the other authors describe interests to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The views expressed in this article are those of the authors and not necessarily those of the NIHR, or the Department of Health and Social Care. AJS is a National Institute for Health Research (NIHR) Senior Investigator. He is director of the NIHR Newcastle Medtech and In Vitro Diagnostics Cooperative, which works with companies across the in vitro diagnostics sector, including work with Becton Dickinson. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: ’I have read the journal’s policy and the authors of this manuscript have the following competing interests: AJS has been an applicant on awarded grants on which Becton Dickinson Biosciences have also been applicants.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting information files.įunding: This work was supported by a grant from the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre awarded to AJS, reference number BH142282 / PD0131 ( ). Received: Accepted: JPublished: July 26, 2022Ĭopyright: © 2022 Funston et al. PLoS ONE 17(7):Įditor: Robert Jeenchen Chen, Stanford University School of Medicine, UNITED STATES
(2022) A human model of bilateral pulmonary vein sampling to assess the effects of one-lung ventilation on neutrophil function. Citation: Funston W, Ruchaud-Sparagano M-H, Scott J, Powell J, Cooles FAH, Shelmerdine L, et al.